Simulations Provide Support for the Common Disease–Common Variant Hypothesis
نویسندگان
چکیده
منابع مشابه
Simulations provide support for the common disease-common variant hypothesis.
The success of mapping genes involved in complex diseases, using association or linkage disequilibrium methods, depends heavily on the number and frequency of susceptibility alleles of these genes. These methods will be economically and statistically feasible if common diseases are usually influenced by one or a few susceptibility alleles at each locus (common disease-common variant, CDCV, hypo...
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While genome-wide linkage studies have been successful in mapping variants underlying rare monogenic disorders, genome-wide association studies may be more appropriate for detecting common variants of modest effects that underlie common disorders. To this end, we were interested in determining whether genetic variants associated with a phenotype differed depending on whether they were within or...
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The recent large genotyping studies have identified a new repertoire of disease susceptibility loci of unknown function, characterized by high allele frequencies and low relative risks, lending support to the common disease-common variant (CDCV) hypothesis. The variants explain a much larger proportion of the disease etiology, measured by the population attributable fraction, than of the famili...
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The investigation of heritable susceptibility to disease is an effort to associate disease phenotype with underlying genotype. Such genotype:phenotype associations have been demonstrated for a large number of monogenetic disorders. The usual strategy has been to use linkage mapping in affected families to identify chromosomal loci from which candidate genes and genotypes can be tested for assoc...
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ژورنال
عنوان ژورنال: Genetics
سال: 2007
ISSN: 1943-2631
DOI: 10.1534/genetics.106.058164